{"id":28,"date":"2026-06-23T09:24:52","date_gmt":"2026-06-23T07:24:52","guid":{"rendered":"https:\/\/themedicinereview.com\/zh-cn\/2026\/06\/23\/%e5%a4%a7%e8%84%91%e8%bf%9e%e6%8e%a5%e6%80%a7%e5%8f%98%e5%8c%96%e6%8f%ad%e7%a4%ba%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e7%9a%84%e6%97%a9%e6%9c%9f%e9%a3%8e%e9%99%a9\/"},"modified":"2026-06-23T09:25:04","modified_gmt":"2026-06-23T07:25:04","slug":"%e5%a4%a7%e8%84%91%e8%bf%9e%e6%8e%a5%e6%80%a7%e5%8f%98%e5%8c%96%e6%8f%ad%e7%a4%ba%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e7%9a%84%e6%97%a9%e6%9c%9f%e9%a3%8e%e9%99%a9","status":"publish","type":"post","link":"https:\/\/themedicinereview.com\/zh-cn\/2026\/06\/23\/%e5%a4%a7%e8%84%91%e8%bf%9e%e6%8e%a5%e6%80%a7%e5%8f%98%e5%8c%96%e6%8f%ad%e7%a4%ba%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e7%9a%84%e6%97%a9%e6%9c%9f%e9%a3%8e%e9%99%a9\/","title":{"rendered":"\u5927\u8111\u8fde\u63a5\u6027\u53d8\u5316\u63ed\u793a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u65e9\u671f\u98ce\u9669"},"content":{"rendered":"

\u5927\u8111\u8fde\u63a5\u6027\u53d8\u5316\u63ed\u793a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u65e9\u671f\u98ce\u9669<\/h1>\n

\u7814\u7a76\u4eba\u5458\u5728\u8ba4\u77e5\u5065\u5eb7\u7684\u8001\u5e74\u4eba\u4e2d\u89c2\u5bdf\u5230\u4e00\u4e2a\u6709\u8da3\u7684\u73b0\u8c61\uff1a\u5927\u8111\u8fde\u63a5\u4e0d\u540c\u533a\u57df\u7684\u65b9\u5f0f\u53d1\u751f\u4e86\u8f6c\u53d8\u3002\u8fd9\u79cd\u53d8\u5316\u8868\u73b0\u4e3a\u5c40\u90e8\u8fde\u63a5\u51cf\u5c11\uff0c\u800c\u8fdc\u7a0b\u8fde\u63a5\u589e\u52a0\uff0c\u53ef\u80fd\u8868\u660e\u60a3\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u65e9\u671f\u98ce\u9669\u3002<\/p>\n

\u8fd9\u9879\u7814\u7a76\u6d89\u53ca86\u540d\u5e74\u9f84\u572865\u81f380\u5c81\u4e4b\u95f4\u3001\u8ba4\u77e5\u529f\u80fd\u6b63\u5e38\u7684\u6210\u5e74\u4eba\u3002\u53c2\u4e0e\u8005\u63a5\u53d7\u4e86\u5927\u8111\u6210\u50cf\u68c0\u67e5\u548c\u8840\u6db2\u5206\u6790\uff0c\u4ee5\u68c0\u6d4b\u4e0e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u76f8\u5173\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002\u5176\u4e2d\uff0c\u90e8\u5206\u53c2\u4e0e\u8005\u5b58\u5728\u6dc0\u7c89\u6837\u86cb\u767d\u6c89\u79ef\uff08\u4e00\u79cd\u4e0e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u76f8\u5173\u7684\u86cb\u767d\u8d28\uff09\uff0c\u6216\u643a\u5e26APOE4\u57fa\u56e0\uff0c\u8be5\u57fa\u56e0\u5df2\u77e5\u4f1a\u589e\u52a0\u60a3\u75c5\u98ce\u9669\u3002<\/p>\n

\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5b58\u5728\u6dc0\u7c89\u6837\u86cb\u767d\u6c89\u79ef\u6216\u643a\u5e26APOE4\u57fa\u56e0\u7684\u53c2\u4e0e\u8005\u5728\u5927\u8111\u7684\u4e00\u4e2a\u533a\u57df\u2014\u2014\u4e0b\u989d\u53f6\u76ae\u5c42\u7684\u5c40\u90e8\u8fde\u63a5\u6027\u51cf\u5f31\u3002\u76f8\u53cd\uff0c\u4ed6\u4eec\u7684\u8fdc\u7a0b\u8fde\u63a5\u5728\u4e0a\u8fd0\u52a8\u76ae\u5c42\u3001\u4e0b\u989d\u56de\u548c\u524d\u5c9b\u53f6\u7b49\u533a\u57df\u66f4\u5f3a\u3002\u8fd9\u4e9b\u533a\u57df\u5728\u6ce8\u610f\u529b\u3001\u8fd0\u52a8\u63a7\u5236\u548c\u60c5\u7eea\u8c03\u8282\u7b49\u8ba4\u77e5\u529f\u80fd\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002<\/p>\n

\u53e6\u4e00\u4e2a\u8840\u6db2\u751f\u7269\u6807\u5fd7\u7269\u2014\u2014\u795e\u7ecf\u4e1d\u8f7b\u94fe\uff0c\u4e5f\u663e\u793a\u51fa\u4e0e\u5927\u8111\u8fde\u63a5\u6027\u7684\u5173\u8054\u3002\u8be5\u6807\u5fd7\u7269\u6c34\u5e73\u5347\u9ad8\uff08\u8868\u660e\u795e\u7ecf\u5143\u53d7\u635f\uff09\u7684\u53c2\u4e0e\u8005\u5728\u5c9b\u53f6\u548c\u6263\u5e26\u76ae\u5c42\u7b49\u533a\u57df\u7684\u5c40\u90e8\u8fde\u63a5\u6027\u66f4\u5f31\u3002\u540c\u65f6\uff0c\u4ed6\u4eec\u7684\u8fdc\u7a0b\u8fde\u63a5\u5728\u6954\u524d\u53f6\u3001\u58f3\u6838\u548c\u4e18\u8111\u7b49\u533a\u57df\u589e\u5f3a\uff0c\u8fd9\u4e9b\u533a\u57df\u90fd\u53c2\u4e0e\u91cd\u8981\u7684\u8ba4\u77e5\u8fc7\u7a0b\u3002<\/p>\n

\u5c40\u90e8\u8fde\u63a5\u6027\u51cf\u5f31\u548c\u8fdc\u7a0b\u8fde\u63a5\u6027\u589e\u5f3a\u4e4b\u95f4\u7684\u8f6c\u53d8\u53ef\u80fd\u53cd\u6620\u51fa\u5927\u8111\u8bd5\u56fe\u8865\u507f\u75be\u75c5\u65e9\u671f\u635f\u4f24\u7684\u5c1d\u8bd5\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u91cd\u7ec4\u4e5f\u53ef\u80fd\u8868\u660e\u795e\u7ecf\u7f51\u7edc\u7684\u4e13\u4e1a\u5316\u7a0b\u5ea6\u4e0b\u964d\uff0c\u4ece\u957f\u8fdc\u6765\u770b\uff0c\u8fd9\u53ef\u80fd\u4f1a\u635f\u5bb3\u8ba4\u77e5\u8868\u73b0\u3002\u7814\u7a76\u4eba\u5458\u6ce8\u610f\u5230\uff0c\u8fdc\u7a0b\u8fde\u63a5\u6027\u7684\u8fd9\u4e9b\u53d8\u5316\u4e0e\u8bb0\u5fc6\u3001\u5904\u7406\u901f\u5ea6\u548c\u6267\u884c\u529f\u80fd\u6d4b\u8bd5\u4e2d\u8f83\u5dee\u7684\u7ed3\u679c\u76f8\u5173\u3002<\/p>\n

\u8fd9\u4e9b\u89c2\u5bdf\u7ed3\u679c\u8868\u660e\uff0c\u5927\u8111\u7684\u7ec4\u7ec7\u548c\u6c9f\u901a\u65b9\u5f0f\u53ef\u80fd\u662f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6613\u611f\u6027\u7684\u4e00\u4e2a\u65e9\u671f\u6307\u6807\uff0c\u8fdc\u5728\u9996\u6b21\u51fa\u73b0\u75c7\u72b6\u4e4b\u524d\u3002\u8fd9\u79cd\u529f\u80fd\u6027\u6807\u5fd7\u7269\u672a\u6765\u53ef\u80fd\u6709\u52a9\u4e8e\u8bc6\u522b\u9ad8\u98ce\u9669\u4eba\u7fa4\uff0c\u5e76\u4ee5\u975e\u4fb5\u5165\u6027\u7684\u65b9\u5f0f\u8ddf\u8e2a\u75be\u75c5\u7684\u8fdb\u5c55\u3002<\/p>\n

\n

Attributions l\u00e9gales<\/h2>\n

Citation de l\u2019\u00e9tude<\/h3>\n

DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1007\/s11357-026-02333-5<\/a><\/p>\n

Titre\u00a0:<\/strong> A local-to-distant shift in dynamic brain connectivity marks early Alzheimer\u2019s risk<\/p>\n

Revue : <\/strong> GeroScience<\/p>\n

\u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n

Auteurs : <\/strong> Andrea Coca-Pulido; Patricio Solis-Urra; Oren Contreras-Rodr\u00edguez; Carles Biarn\u00e9s; Marcos Olvera-Rojas; Shivangi Jain; Anuradha Sehrawat; Yijun Chen; Yolanda Garc\u00eda-Rivero; Manuel Gomez-Rio; Kirk I. Erickson; Jose Mora-Gonzalez; Irene Esteban-Cornejo<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5927\u8111\u8fde\u63a5\u6027\u53d8\u5316\u63ed\u793a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u65e9\u671f\u98ce\u9669 \u7814\u7a76\u4eba\u5458\u5728\u8ba4\u77e5\u5065\u5eb7\u7684\u8001\u5e74\u4eba\u4e2d\u89c2\u5bdf\u5230\u4e00\u4e2a\u6709\u8da3\u7684\u73b0\u8c61\uff1a\u5927\u8111\u8fde\u63a5\u4e0d\u540c\u533a\u57df\u7684… \u7ee7\u7eed\u9605\u8bfb\u5927\u8111\u8fde\u63a5\u6027\u53d8\u5316\u63ed\u793a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u65e9\u671f\u98ce\u9669<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[],"class_list":["post-28","post","type-post","status-publish","format-standard","hentry","category-8","category-2","entry"],"_links":{"self":[{"href":"https:\/\/themedicinereview.com\/zh-cn\/wp-json\/wp\/v2\/posts\/28","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/themedicinereview.com\/zh-cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/themedicinereview.com\/zh-cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/themedicinereview.com\/zh-cn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/themedicinereview.com\/zh-cn\/wp-json\/wp\/v2\/comments?post=28"}],"version-history":[{"count":1,"href":"https:\/\/themedicinereview.com\/zh-cn\/wp-json\/wp\/v2\/posts\/28\/revisions"}],"predecessor-version":[{"id":29,"href":"https:\/\/themedicinereview.com\/zh-cn\/wp-json\/wp\/v2\/posts\/28\/revisions\/29"}],"wp:attachment":[{"href":"https:\/\/themedicinereview.com\/zh-cn\/wp-json\/wp\/v2\/media?parent=28"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/themedicinereview.com\/zh-cn\/wp-json\/wp\/v2\/categories?post=28"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/themedicinereview.com\/zh-cn\/wp-json\/wp\/v2\/tags?post=28"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}