{"id":15,"date":"2026-03-24T23:41:15","date_gmt":"2026-03-24T22:41:15","guid":{"rendered":"https:\/\/themedicinereview.com\/vi\/2026\/03\/24\/mot-phan-tu-moi-day-hua-hen-chong-lai-vi-khuan-khang-khang-sinh\/"},"modified":"2026-03-24T23:42:47","modified_gmt":"2026-03-24T22:42:47","slug":"mot-phan-tu-moi-day-hua-hen-chong-lai-vi-khuan-khang-khang-sinh","status":"publish","type":"post","link":"https:\/\/themedicinereview.com\/vi\/2026\/03\/24\/mot-phan-tu-moi-day-hua-hen-chong-lai-vi-khuan-khang-khang-sinh\/","title":{"rendered":"M\u1ed9t ph\u00e2n t\u1eed m\u1edbi \u0111\u1ea7y h\u1ee9a h\u1eb9n ch\u1ed1ng l\u1ea1i vi khu\u1ea9n kh\u00e1ng kh\u00e1ng sinh"},"content":{"rendered":"

M\u1ed9t ph\u00e2n t\u1eed m\u1edbi \u0111\u1ea7y h\u1ee9a h\u1eb9n ch\u1ed1ng l\u1ea1i vi khu\u1ea9n kh\u00e1ng kh\u00e1ng sinh<\/h1>\n

Vi khu\u1ea9n kh\u00e1ng kh\u00e1ng sinh, nh\u01b0 t\u1ee5 c\u1ea7u v\u00e0ng kh\u00e1ng methicillin ho\u1eb7c tr\u1ef1c khu\u1ea9n lao \u0111a kh\u00e1ng, l\u00e0 m\u1ed9t th\u00e1ch th\u1ee9c l\u1edbn \u0111\u1ed1i v\u1edbi y h\u1ecdc hi\u1ec7n \u0111\u1ea1i. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t tri\u1ec3n m\u1ed9t h\u1ecd c\u00e1c h\u1ee3p ch\u1ea5t h\u00f3a h\u1ecdc k\u1ebft h\u1ee3p hai c\u1ea5u tr\u00fac \u0111\u00e3 bi\u1ebft v\u1edbi t\u00ednh ch\u1ea5t kh\u00e1ng khu\u1ea9n: tetrazol v\u00e0 thiourea. Nh\u1eefng ph\u00e2n t\u1eed lai n\u00e0y c\u00f3 th\u1ec3 cung c\u1ea5p m\u1ed9t gi\u1ea3i ph\u00e1p hi\u1ec7u qu\u1ea3 ch\u1ed1ng l\u1ea1i c\u00e1c nhi\u1ec5m tr\u00f9ng kh\u00f3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n

Trong s\u1ed1 nh\u1eefng h\u1ee3p ch\u1ea5t n\u00e0y, m\u1ed9t h\u1ee3p ch\u1ea5t n\u1ed5i b\u1eadt \u0111\u1eb7c bi\u1ec7t. N\u00f3 mang m\u1ed9t nh\u00f3m trifluoromethyl v\u00e0 th\u1ec3 hi\u1ec7n ho\u1ea1t t\u00ednh \u0111\u00e1ng ch\u00fa \u00fd ch\u1ed1ng l\u1ea1i nhi\u1ec1u ch\u1ee7ng t\u1ee5 c\u1ea7u, bao g\u1ed3m c\u1ea3 nh\u1eefng ch\u1ee7ng kh\u00e1ng nhi\u1ec1u lo\u1ea1i kh\u00e1ng sinh. Hi\u1ec7u qu\u1ea3 c\u1ee7a n\u00f3 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi ciprofloxacin, m\u1ed9t lo\u1ea1i kh\u00e1ng sinh th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng. H\u01a1n n\u1eefa, n\u00f3 c\u0169ng t\u00e1c \u0111\u1ed9ng l\u00ean b\u1ec7nh lao, bao g\u1ed3m c\u1ea3 c\u00e1c d\u1ea1ng \u0111a kh\u00e1ng v\u00e0 si\u00eau kh\u00e1ng, v\u1edbi n\u1ed3ng \u0111\u1ed9 \u1ee9c ch\u1ebf t\u1ed1i thi\u1ec3u r\u1ea5t th\u1ea5p.<\/p>\n

C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 nghi\u00ean c\u1ee9u c\u00e1ch ph\u00e2n t\u1eed n\u00e0y t\u01b0\u01a1ng t\u00e1c v\u1edbi hai protein vi khu\u1ea9n thi\u1ebft y\u1ebfu: dihydrofolate reductase, li\u00ean quan \u0111\u1ebfn t\u1ed5ng h\u1ee3p DNA, v\u00e0 m\u1ed9t protein li\u00ean quan \u0111\u1ebfn s\u1ef1 h\u00ecnh th\u00e0nh th\u00e0nh t\u1ebf b\u00e0o vi khu\u1ea9n. C\u00e1c m\u00f4 ph\u1ecfng tr\u00ean m\u00e1y t\u00ednh cho th\u1ea5y n\u00f3 c\u00f3 th\u1ec3 ch\u1eb7n \u0111\u1ed3ng th\u1eddi c\u1ea3 hai m\u1ee5c ti\u00eau n\u00e0y, \u0111i\u1ec1u n\u00e0y gi\u1ea3i th\u00edch cho ph\u1ed5 t\u00e1c \u0111\u1ed9ng r\u1ed9ng c\u1ee7a n\u00f3. C\u00e1ch ti\u1ebfp c\u1eadn k\u00e9p n\u00e0y c\u0169ng gi\u1ea3m nguy c\u01a1 vi khu\u1ea9n ph\u00e1t tri\u1ec3n kh\u00e1ng thu\u1ed1c.<\/p>\n

C\u00e1c th\u1eed nghi\u1ec7m trong ph\u00f2ng th\u00ed nghi\u1ec7m x\u00e1c nh\u1eadn r\u1eb1ng h\u1ee3p ch\u1ea5t n\u00e0y ho\u1ea1t \u0111\u1ed9ng \u1edf li\u1ec1u l\u01b0\u1ee3ng r\u1ea5t th\u1ea5p, m\u00e0 kh\u00f4ng g\u00e2y \u0111\u1ed9c t\u00ednh cho c\u00e1c t\u1ebf b\u00e0o ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh. N\u00f3 c\u0169ng s\u1edf h\u1eefu c\u00e1c t\u00ednh ch\u1ea5t v\u1eadt l\u00fd-h\u00f3a h\u1ecdc thu\u1eadn l\u1ee3i cho vi\u1ec7c s\u1eed d\u1ee5ng trong t\u01b0\u01a1ng lai nh\u01b0 m\u1ed9t lo\u1ea1i thu\u1ed1c, ch\u1eb3ng h\u1ea1n nh\u01b0 kh\u1ea3 n\u0103ng xuy\u00ean m\u00e0ng t\u1ebf b\u00e0o t\u1ed1t.<\/p>\n

Nh\u1eefng k\u1ebft qu\u1ea3 n\u00e0y m\u1edf ra con \u0111\u01b0\u1eddng cho c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi ch\u1ed1ng l\u1ea1i c\u00e1c nhi\u1ec5m tr\u00f9ng kh\u00e1ng thu\u1ed1c. Ph\u00e2n t\u1eed \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e0m c\u01a1 s\u1edf \u0111\u1ec3 ph\u00e1t tri\u1ec3n c\u00e1c lo\u1ea1i kh\u00e1ng sinh m\u1ea1nh h\u01a1n v\u00e0 \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t h\u01a1n, c\u00f3 kh\u1ea3 n\u0103ng v\u01b0\u1ee3t qua c\u00e1c c\u01a1 ch\u1ebf kh\u00e1ng thu\u1ed1c hi\u1ec7n t\u1ea1i. C\u00e1c b\u01b0\u1edbc ti\u1ebfp theo s\u1ebd l\u00e0 tinh ch\u1ec9nh c\u1ea5u tr\u00fac c\u1ee7a n\u00f3 \u0111\u1ec3 t\u1ed1i \u01b0u h\u00f3a hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 an to\u00e0n tr\u01b0\u1edbc khi ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng.<\/p>\n

\n

Attributions l\u00e9gales<\/h2>\n

Citation de l\u2019\u00e9tude<\/h3>\n

DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1007\/s43440-026-00848-4<\/a><\/p>\n

Titre\u00a0:<\/strong> Discovery of a tetrazole-thiourea derivative as a potential active agent against multidrug-resistant Staphylococcus aureus and Mycobacterium tuberculosis<\/p>\n

Revue : <\/strong> Pharmacological Reports<\/p>\n

\u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n

Auteurs : <\/strong> Jolanta Szyma\u0144ska-Majchrzak; Agnieszka G\u0142ogowska; Ewa Augustynowicz-Kope\u0107; Katarzyna Ewa Greber; Krzesimir Ciura; Wioletta Olejarz; Tomasz Szostek; Marta Struga; Daniel Szulczyk<\/p>\n","protected":false},"excerpt":{"rendered":"

M\u1ed9t ph\u00e2n t\u1eed m\u1edbi \u0111\u1ea7y h\u1ee9a h\u1eb9n ch\u1ed1ng l\u1ea1i vi khu\u1ea9n kh\u00e1ng kh\u00e1ng sinh Vi khu\u1ea9n kh\u00e1ng kh\u00e1ng sinh, nh\u01b0 t\u1ee5 c\u1ea7u v\u00e0ng kh\u00e1ng methicillin ho\u1eb7c tr\u1ef1c khu\u1ea9n lao \u0111a kh\u00e1ng, l\u00e0 m\u1ed9t th\u00e1ch th\u1ee9c l\u1edbn \u0111\u1ed1i v\u1edbi y h\u1ecdc hi\u1ec7n \u0111\u1ea1i. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t tri\u1ec3n m\u1ed9t h\u1ecd c\u00e1c h\u1ee3p ch\u1ea5t h\u00f3a… Continue reading M\u1ed9t ph\u00e2n t\u1eed m\u1edbi \u0111\u1ea7y h\u1ee9a h\u1eb9n ch\u1ed1ng l\u1ea1i vi khu\u1ea9n kh\u00e1ng kh\u00e1ng sinh<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-15","post","type-post","status-publish","format-standard","hentry","category-suc-khoe","entry"],"_links":{"self":[{"href":"https:\/\/themedicinereview.com\/vi\/wp-json\/wp\/v2\/posts\/15","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/themedicinereview.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/themedicinereview.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/themedicinereview.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/themedicinereview.com\/vi\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":1,"href":"https:\/\/themedicinereview.com\/vi\/wp-json\/wp\/v2\/posts\/15\/revisions"}],"predecessor-version":[{"id":16,"href":"https:\/\/themedicinereview.com\/vi\/wp-json\/wp\/v2\/posts\/15\/revisions\/16"}],"wp:attachment":[{"href":"https:\/\/themedicinereview.com\/vi\/wp-json\/wp\/v2\/media?parent=15"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/themedicinereview.com\/vi\/wp-json\/wp\/v2\/categories?post=15"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/themedicinereview.com\/vi\/wp-json\/wp\/v2\/tags?post=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}