Baz\u0131 sinirlerin elektriksel uyar\u0131m\u0131, \u015fiddetli kanamalar\u0131 azaltmak i\u00e7in yeni bir yakla\u015f\u0131m sunabilir. Yak\u0131n zamanda yap\u0131lan bir \u00e7al\u0131\u015fma, sa\u011fl\u0131kl\u0131 g\u00f6n\u00fcll\u00fclerde aurik\u00fcler vagus sinirinin transk\u00fctan uyar\u0131m\u0131n\u0131n veya vagus ve trigeminal sinirlerin kombine uyar\u0131m\u0131n\u0131n, kan trombositlerinin i\u015flevleri ve p\u0131ht\u0131la\u015fma parametreleri \u00fczerindeki etkisini inceledi.<\/p>\n
Travma veya cerrahi m\u00fcdahale nedeniyle olu\u015fan kanamalar, d\u00fcnya \u00e7ap\u0131nda \u00f6l\u00fcmlere yol a\u00e7an ba\u015fl\u0131ca nedenler aras\u0131nda yer almaya devam ediyor. T\u0131bbi ilerlemelere ra\u011fmen, turnike veya farmakolojik ajanlar gibi mevcut \u00e7\u00f6z\u00fcmlerin s\u0131n\u0131rl\u0131l\u0131klar\u0131 bulunmaktad\u0131r. Bu y\u00f6ntemler genellikle \u00e7ok ge\u00e7 tepki vermektedir veya s\u0131k\u0131\u015ft\u0131r\u0131lamayan b\u00f6lgeleri hedef almakta zorlanmakta, ayr\u0131ca dokulara zarar verme veya v\u00fccudun di\u011fer b\u00f6lgelerinde istenmeyen p\u0131ht\u0131lar olu\u015fturma riski ta\u015f\u0131maktad\u0131r. Dahas\u0131, g\u00fcn\u00fcm\u00fczde onaylanm\u0131\u015f hi\u00e7bir y\u00f6ntem, p\u0131ht\u0131 olu\u015fumunda kritik \u00f6neme sahip olan trombositleri do\u011frudan uyaramamaktad\u0131r.<\/p>\n
Biyoelektronik t\u0131p, sinir sisteminin aktivitesini mod\u00fcle etmek i\u00e7in elektriksel sinyaller kullanan bir aland\u0131r ve yeni ufuklar a\u00e7maktad\u0131r. Daha \u00f6nce yap\u0131lan ara\u015ft\u0131rmalar, vagus sinirinin uyar\u0131m\u0131n\u0131n, dalaktaki lenfositlerin asetilkolin salg\u0131lamas\u0131 yoluyla hayvanlardaki kanamalar\u0131 azaltt\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015fti. Bu molek\u00fcl daha sonra trombositlerin nikotinik resept\u00f6rlerini aktive ederek, h\u00fccre i\u00e7i kalsiyum konsantrasyonlar\u0131n\u0131 art\u0131r\u0131r. Priming<\/em> ad\u0131 verilen bu s\u00fcre\u00e7, trombositleri yaralanma durumunda daha h\u0131zl\u0131 tepki verebilmeleri i\u00e7in haz\u0131rlar ve b\u00f6ylece p\u0131ht\u0131 olu\u015fumunu h\u0131zland\u0131r\u0131r.<\/p>\n Bu \u00e7al\u0131\u015fmada, sa\u011fl\u0131kl\u0131 24 yeti\u015fkine aurik\u00fcler vagus sinirinin transk\u00fctan uyar\u0131m\u0131 veya vagus ve trigeminal sinirlerin kombine uyar\u0131m\u0131 uyguland\u0131. Sonu\u00e7lar, her iki y\u00f6ntemin de trombositleri aktive etti\u011fini, ancak farkl\u0131 mekanizmalar arac\u0131l\u0131\u011f\u0131yla oldu\u011funu ortaya koydu. Aurik\u00fcler vagus sinirinin uyar\u0131m\u0131, p\u0131ht\u0131la\u015fmada anahtar role sahip olan kolajene kar\u015f\u0131 trombosit yan\u0131t\u0131n\u0131 h\u0131zland\u0131r\u0131rken, kombine uyar\u0131m ADP\u2019ye kar\u015f\u0131 duyarl\u0131l\u0131klar\u0131n\u0131 art\u0131rd\u0131; ADP, trombosit agregasyonunda rol oynayan ba\u015fka bir molek\u00fcld\u00fcr.<\/p>\n Buna ek olarak, aurik\u00fcler vagus sinirinin uyar\u0131m\u0131n\u0131n p\u0131ht\u0131la\u015fma kineti\u011fi \u00fczerinde dikkate de\u011fer bir etkisi oldu\u011fu kan\u0131tland\u0131. Tromboelastografi ad\u0131 verilen ve p\u0131ht\u0131lar\u0131n dayan\u0131kl\u0131l\u0131\u011f\u0131n\u0131 ve olu\u015fum h\u0131z\u0131n\u0131 de\u011ferlendiren bir teknikle \u00f6l\u00e7\u00fcld\u00fc\u011f\u00fc \u00fczere, p\u0131ht\u0131 olu\u015fumunun ba\u015flat\u0131lmas\u0131, yay\u0131lmas\u0131 ve stabilize edilmesi i\u00e7in gereken s\u00fcreyi k\u0131saltmaktad\u0131r. Kat\u0131l\u0131mc\u0131larda herhangi bir yan etki g\u00f6zlenmemi\u015f olup, bu yakla\u015f\u0131mlar\u0131n iyi tolere edildi\u011fi do\u011frulanm\u0131\u015ft\u0131r.<\/p>\n Bu bulgular, sinir uyar\u0131m\u0131n\u0131n, \u00f6zellikle \u015fiddetli travmalar, cerrahiler veya baz\u0131 kanama bozukluklar\u0131 gibi kanamalar\u0131n kontrol alt\u0131na al\u0131nmas\u0131n\u0131n zor oldu\u011fu durumlarda, p\u0131ht\u0131la\u015fmay\u0131 iyile\u015ftirmek i\u00e7in invaziv olmayan bir \u00e7\u00f6z\u00fcm haline gelebilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir. Bu sonu\u00e7lar\u0131 do\u011frulamak i\u00e7in ek klinik deneylerin gerekli olmas\u0131na ra\u011fmen, bu \u00e7al\u0131\u015fma kanamalara kar\u015f\u0131 daha etkili ve g\u00fcvenli tedavilere do\u011fru \u00f6nemli bir ad\u0131m olarak kabul edilebilir.<\/p>\n DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1186\/s42234-026-00208-w<\/a><\/p>\n Titre\u00a0:<\/strong> Effects of transcutaneous auricular vagus nerve stimulation or combined vagal and trigeminal nerve stimulation on platelet function and laboratory hemostasis parameters in healthy human subjects<\/p>\n Revue : <\/strong> Bioelectronic Medicine<\/p>\n \u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n Auteurs : <\/strong> Jared M. Huston; Carlos E. Bravo-I\u00f1iguez; Julien Papoin; Maaryj Ahmad; Brooke Le; Isabella Mirro; Melanie McWade; Caroline Benner; Alejandro Covalin; Christopher J. Czura; Navid Khodaparast; Lionel Blanc<\/p>\n","protected":false},"excerpt":{"rendered":" Sinir uyar\u0131m\u0131 kan p\u0131ht\u0131la\u015fmas\u0131n\u0131 iyile\u015ftirir Baz\u0131 sinirlerin elektriksel uyar\u0131m\u0131, \u015fiddetli kanamalar\u0131 azaltmak i\u00e7in yeni bir yakla\u015f\u0131m sunabilir. Yak\u0131n zamanda yap\u0131lan bir \u00e7al\u0131\u015fma, sa\u011fl\u0131kl\u0131 g\u00f6n\u00fcll\u00fclerde aurik\u00fcler vagus sinirinin transk\u00fctan uyar\u0131m\u0131n\u0131n veya vagus ve trigeminal sinirlerin kombine uyar\u0131m\u0131n\u0131n, kan trombositlerinin i\u015flevleri ve p\u0131ht\u0131la\u015fma parametreleri \u00fczerindeki etkisini inceledi. Travma veya cerrahi m\u00fcdahale nedeniyle olu\u015fan kanamalar, d\u00fcnya \u00e7ap\u0131nda \u00f6l\u00fcmlere… Okumaya devam et Sinir uyar\u0131m\u0131 kan p\u0131ht\u0131la\u015fmas\u0131n\u0131 iyile\u015ftirir<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,5],"tags":[],"class_list":["post-18","post","type-post","status-publish","format-standard","hentry","category-saglik","category-uluslararasi","entry"],"_links":{"self":[{"href":"https:\/\/themedicinereview.com\/tr\/wp-json\/wp\/v2\/posts\/18","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/themedicinereview.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/themedicinereview.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/themedicinereview.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/themedicinereview.com\/tr\/wp-json\/wp\/v2\/comments?post=18"}],"version-history":[{"count":1,"href":"https:\/\/themedicinereview.com\/tr\/wp-json\/wp\/v2\/posts\/18\/revisions"}],"predecessor-version":[{"id":19,"href":"https:\/\/themedicinereview.com\/tr\/wp-json\/wp\/v2\/posts\/18\/revisions\/19"}],"wp:attachment":[{"href":"https:\/\/themedicinereview.com\/tr\/wp-json\/wp\/v2\/media?parent=18"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/themedicinereview.com\/tr\/wp-json\/wp\/v2\/categories?post=18"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/themedicinereview.com\/tr\/wp-json\/wp\/v2\/tags?post=18"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nAttributions l\u00e9gales<\/h2>\n
Citation de l\u2019\u00e9tude<\/h3>\n