“`html<\/p>\n
\uad00\uc808\uc5fc\uc740 \uc804 \uc138\uacc4 5\uc5b5 \uba85 \uc774\uc0c1\uc5d0\uac8c \uc601\ud5a5\uc744 \ubbf8\uce58\uba70 \uadf8\ub4e4\uc758 \uc0b6\uc758 \uc9c8\uc744 \ud06c\uac8c \uc800\ud574\ud55c\ub2e4. \uc624\ub7ab\ub3d9\uc548 \uc5f0\uace8\uc758 \ub9c8\ubaa8\uc640 \uad00\ub828\ub41c \uc9c8\ubcd1\uc73c\ub85c \uc5ec\uaca8\uc84c\uc9c0\ub9cc, \ud604\uc7ac\ub294 \uad00\uc808 \uc804\uccb4\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uc9c8\ubcd1\uc73c\ub85c \uc778\uc2dd\ub418\uace0 \uc788\uc73c\uba70, \uc774\ub294 \ubf08, \uc778\ub300, \ud65c\uc561\ub9c9 \ubc0f \uae30\ud0c0 \uc870\uc9c1\ub4e4\uc744 \ud3ec\ud568\ud55c\ub2e4. \ud56d\uc5fc\uc99d\uc81c\ub098 \uc2a4\ud14c\ub85c\uc774\ub4dc\uc640 \uac19\uc740 \uc804\ud1b5\uc801\uc778 \uce58\ub8cc\ubc95\uc740 \uc99d\uc0c1\uc744 \uc644\ud654\uc2dc\ud0ac \uc218\ub294 \uc788\uc9c0\ub9cc, \uc9c8\ubcd1\uc758 \uc9c4\ud589\uc744 \uba48\ucd94\uac70\ub098 \uad00\uc808 \uae30\ub2a5\uc744 \ud68c\ubcf5\uc2dc\ud0a4\ub294 \ub370\ub294 \ud6a8\uacfc\uac00 \uc5c6\ub2e4.<\/p>\n
\uad00\uc808\uc5fc\uc758 \uc6d0\uc778\uc740 \ubcf5\uc7a1\ud558\uace0 \ub2e4\uc778\uc790\uc801\uc774\ub2e4. \ub178\ud654, \uc720\uc804\uc801 \uc18c\uc778, \ube44\ub9cc, \uad00\uc808 \uc190\uc0c1 \ub610\ub294 \ub9cc\uc131 \uc800\ub4f1\uae09 \uc5fc\uc99d \ub4f1\uc774 \uc870\uc9c1\uc758 \ud30c\uad34\uc640 \uc218\ubcf5 \uc0ac\uc774\uc758 \uade0\ud615\uc744 \uae68\ub728\ub9b0\ub2e4. \uc774\ub7ec\ud55c \ubd88\uade0\ud615\uc740 \uc5f0\uace8\uc758 \uc810\uc9c4\uc801\uc778 \uc190\uc0c1, \uc5f0\uace8 \uc544\ub798 \ubf08\uc758 \ubcc0\ud654, \ud65c\uc561\ub9c9\uc758 \uc5fc\uc99d, \uadf8\ub9ac\uace0 \uacb0\uad6d \uc6b4\ub3d9 \uae30\ub2a5\uc758 \uc0c1\uc2e4\uc744 \ucd08\ub798\ud55c\ub2e4. \ud1b5\uc99d\uc740 \uc885\uc885 \uccab \ubc88\uc9f8 \uc2e0\ud638\ub85c, \uc601\uc0c1 \uac80\uc0ac\uc5d0\uc11c \ubcd1\ubcc0\uc774 \ubcf4\uc774\uae30 \uc804\uc5d0 \ub098\ud0c0\ub098\uae30\ub3c4 \ud55c\ub2e4. \ud1b5\uc99d\uc740 \uc2e0\uacbd\uc758 \uacfc\ubbfc\uc131, \uad6d\uc18c \uc5fc\uc99d, \uad00\uc808\uc758 \uad6c\uc870\uc801 \ubcc0\ud654 \ub4f1 \ub2e4\uc591\ud55c \uba54\ucee4\ub2c8\uc998\uc5d0 \uc758\ud574 \ubc1c\uc0dd\ud55c\ub2e4.<\/p>\n
\ucd5c\uadfc\uc758 \uc5f0\uad6c\ub97c \ud1b5\ud574 \uad00\uc808\uc5fc\uc758 \uc0dd\ubb3c\ud559\uc801 \uacfc\uc815\uc5d0 \ub300\ud55c \uc774\ud574\uac00 \uae4a\uc5b4\uc84c\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc5f0\uace8\uc758 \uade0\ud615\uc744 \uc720\uc9c0\ud558\ub294 \ub370 \ud544\uc218\uc801\uc778 Wnt \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\uac00 \uad50\ub780\ub420 \uc218 \uc788\ub2e4. \uc774 \uacbd\ub85c\uac00 \uacfc\ub3c4\ud558\uac8c \ud65c\uc131\ud654\ub418\uba74 \uc5f0\uace8\uc744 \ubd84\ud574\ud558\ub294 \ud6a8\uc18c\ub97c \uc0dd\uc131\ud558\ub294 \uac83\uc744 \ucd09\uc9c4\ud55c\ub2e4. \ubc18\ub300\ub85c, FrzB\uc640 \uac19\uc740 \ud2b9\uc815 \ub2e8\ubc31\uc9c8\uc740 \uc774 \uacbd\ub85c\uc758 \uc790\uc5f0\uc801\uc778 \uc5b5\uc81c\uc81c\ub85c \uc791\uc6a9\ud558\uc5ec \uc5f0\uace8\uc744 \ubcf4\ud638\ud55c\ub2e4. \ub610\ud55c, TGF-\u03b2 \uacbd\ub85c\ub3c4 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4. \uc774 \uacbd\ub85c\uc758 \uae30\ub2a5 \uc7a5\uc560\ub294 \uc5f0\uace8\uc758 \ubd84\ud574\ub97c \uac00\uc18d\ud654\ud558\uace0, \ubf08 \ub3cc\uae30(\uace8\uc721\uc885)\ub77c\uace0 \ubd88\ub9ac\ub294 \ubf08\uc758 \ub3cc\uae30\ub97c \ud615\uc131\ud558\uc5ec \uc99d\uc0c1\uc744 \uc545\ud654\uc2dc\ud0a8\ub2e4.<\/p>\n
\uc720\uc804\uc790\ub3c4 \uad00\uc808\uc5fc\uc5d0 \ub300\ud55c \uac10\uc218\uc131\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce5c\ub2e4. \uc720\uc804\uc801 \ubcc0\uc774\ub294 \uad00\uc808 \uc870\uc9c1\uc774 \uae30\uacc4\uc801 \uc2a4\ud2b8\ub808\uc2a4\ub098 \uc5fc\uc99d\uc5d0 \ubc18\uc751\ud558\ub294 \ubc29\uc2dd\uc744 \ubcc0\uacbd\ud560 \uc218 \uc788\ub2e4. \uc608\ub97c \ub4e4\uc5b4, Axin2 \uc720\uc804\uc790\uc758 \ub3cc\uc5f0\ubcc0\uc774\ub294 Wnt \uacbd\ub85c\uc758 \uc870\uc808\uc744 \ubc29\ud574\ud558\uc5ec \uc5f0\uace8\uc758 \ud30c\uad34\ub97c \uac00\uc18d\ud654\ud560 \uc218 \uc788\ub2e4. \ub610\ud55c, \uc0dd\uc2dd\uacfc \uad00\ub828\ub41c \ud638\ub974\ubaac \uc694\uc778\ub4e4\ub3c4 \uc9c8\ubcd1\uc758 \ubc1c\ubcd1\uc5d0 \uc5b4\ub5a4 \uc5ed\ud560\uc744 \ud558\ub294 \uac83\uc73c\ub85c \ubcf4\uc774\ub098, \uc815\ud655\ud55c \uba54\ucee4\ub2c8\uc998\uc740 \uc544\uc9c1 \uba85\ud655\ud788 \ubc1d\ud600\uc9c0\uc9c0 \uc54a\uc558\ub2e4.<\/p>\n
\uad00\uc808\uc5fc\uc740 \ubaa8\ub4e0 \ud658\uc790\uc5d0\uc11c \ub3d9\uc77c\ud558\uac8c \ub098\ud0c0\ub098\uc9c0\ub294 \uc54a\ub294\ub2e4. \uc6b0\uc138\ud55c \uba54\ucee4\ub2c8\uc998\uc5d0 \ub530\ub77c \uc5ec\ub7ec \ud615\ud0dc \ub610\ub294 \ud45c\ud615\uc774 \uad6c\ubcc4\ub41c\ub2e4. \uc77c\ubd80 \ud658\uc790\ub294 \ud65c\uc561\ub9c9\uc758 \uc2ec\ud55c \uc5fc\uc99d\uc744 \ubcf4\uc774\uba70, \ub2e4\ub978 \ud658\uc790\ub294 \ub300\uc0ac \ubd88\uade0\ud615, \uc608\ub97c \ub4e4\uc5b4 \ub300\uc0ac \uc99d\ud6c4\uad70\uc774\ub098 \uad00\uc808\uc5d0 \uac00\ud574\uc9c0\ub294 \ud558\uc911\uc758 \uc798\ubabb\ub41c \ubd84\ud3ec\uc640 \uac19\uc740 \uae30\uacc4\uc801 \ubb38\uc81c\ub85c \uace0\ud1b5\ubc1b\ub294\ub2e4. \ub610 \ub2e4\ub978 \ud615\ud0dc\ub294 \ub178\ud654\ub41c \uc138\ud3ec\uc758 \ucd95\uc801\uacfc \uad00\ub828\uc774 \uc788\ub294\ub370, \uc774\ub7ec\ud55c \uc138\ud3ec\ub294 \uc5fc\uc99d\uc744 \ucd09\uc9c4\ud558\ub294 \ubb3c\uc9c8\uc744 \ubd84\ube44\ud558\uc5ec \uc5f0\uace8\uc758 \ud30c\uad34\ub97c \uc545\ud654\uc2dc\ud0a8\ub2e4. \uc774\ub7ec\ud55c \ub2e4\uc591\ud55c \ud504\ub85c\ud30c\uc77c\uc744 \uc2dd\ubcc4\ud568\uc73c\ub85c\uc368 \uac01 \ud658\uc790\uc5d0\uac8c \ub9de\ucda4\ud615 \uce58\ub8cc\ub97c \uace0\ub824\ud560 \uc218 \uc788\ub2e4.<\/p>\n
\ud604\uc7ac\uc758 \uce58\ub8cc \uc811\uadfc\ubc95\uc740 \uc9c8\ubcd1\uc758 \uadfc\ubcf8 \uc6d0\uc778\uc5d0 \uc791\uc6a9\ud560 \uc218 \uc788\ub294 \uc0c8\ub85c\uc6b4 \ubc29\ubc95\uc744 \ud0d0\uad6c\ud558\uace0 \uc788\ub2e4. \uadf8 \uc911 \uc7ac\uc0dd \uce58\ub8cc\ub294 \uc190\uc0c1\ub41c \uc5f0\uace8\uc744 \uc218\ub9ac\ud558\uae30 \uc704\ud574 \uc0c8\ub85c\uc6b4 \uc138\ud3ec\uc758 \uc131\uc7a5\uc744 \uc790\uadf9\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \ud55c\ub2e4. interleukin-1 \ub610\ub294 interleukin-6\uc758 \uc5b5\uc81c\uc81c\uc640 \uac19\uc740 \ud45c\uc801 \ud56d\uc5fc\uc99d\uc81c\ub294 \uc5fc\uc99d\uacfc \uc5f0\uace8 \ud30c\uad34\ub97c \uc77c\uc73c\ud0a4\ub294 \ubd84\uc790\ub97c \ud2b9\uc815\ud558\uc5ec \ucc28\ub2e8\ud558\ub824 \ud55c\ub2e4. \ub610 \ub2e4\ub978 \ud601\uc2e0\uc801\uc778 \uc804\ub7b5\uc740 \ub178\ud654\ub41c \uc138\ud3ec\ub97c \uc81c\uac70\ud558\uac70\ub098 \uadf8\ub4e4\uc758 \ud589\ub3d9\uc744 \uc218\uc815\ud558\uc5ec \uad00\uc808\uc5d0 \ubbf8\uce58\ub294 \uc720\ud574\ud55c \uc601\ud5a5\uc744 \uc904\uc774\ub294 \uac83\uc774\ub2e4.<\/p>\n
\uc5f0\uace8 \uc544\ub798 \ubf08\ub97c \ud45c\uc801\uc73c\ub85c \ud558\ub294 \uce58\ub8cc\ubc95\ub3c4 \uc5f0\uad6c \uc911\uc774\ub2e4. strontium ranelate\ub098 denosumab\uacfc \uac19\uc740 \uc57d\ubb3c\uc740 \ubf08\uc758 \uc7ac\ud615\uc131\uc744 \ud1b5\ud574 \uc5f0\uace8\uc758 \ud30c\uad34\ub97c \uc608\ubc29\ud558\uace0 \ud1b5\uc99d\uc744 \uc644\ud654\ud55c\ub2e4. \ube44\ud0c0\ubbfc D\uc640 \uce7c\uc298\uc740 \ub35c \uac15\ub825\ud558\uc9c0\ub9cc \ubf08\uc758 \uac74\uac15\uc744 \uc720\uc9c0\ud558\uace0 \uc5fc\uc99d\uc744 \uc904\uc774\ub294 \ub370 \uae30\uc5ec\ud55c\ub2e4. \ub3d9\uc2dc\uc5d0, hyaluronic acid\ub098 \ud608\uc18c\ud310 \ud48d\ubd80 \ud608\uc7a5(PRP)\uacfc \uac19\uc740 \uce58\ub8cc\ubc95\uc740 \uad00\uc808\uc758 \uc724\ud65c\uc744 \uac1c\uc120\ud558\uace0 \uc870\uc9c1\uc758 \uc218\ub9ac\ub97c \ucd09\uc9c4\ud558\ub294 \ub370 \uc0ac\uc6a9\ub41c\ub2e4.<\/p>\n
\uc5f0\uace8\uc744 \ubd84\ud574\ud558\ub294 \ud6a8\uc18c\uc778 metalloproteinase\uc758 \uc5b5\uc81c\uc81c\ub294 \uc2e4\ud5d8\uc2e4\uc5d0\uc11c \uc720\ub9dd\ud55c \uacb0\uacfc\ub97c \ubcf4\uc600\uc9c0\ub9cc, \uc784\uc0c1\uc801 \uc0ac\uc6a9\uc5d0\uc11c\ub294 \ubd80\uc791\uc6a9\uacfc \ud2b9\uc774\uc131\uc758 \ubd80\uc871\uc73c\ub85c \uc778\ud574 \uc5b4\ub824\uc6c0\uc744 \uacaa\uace0 \uc788\ub2e4. \uc138\ud3ec \ub300\uc0ac\ub97c \uc870\uc808\ud558\ub294 \ub2e8\ubc31\uc9c8\uc778 AMPK\uc758 \ud65c\uc131\ud654\uc81c\ub294 \ub610 \ub2e4\ub978 \ud765\ubbf8\ub85c\uc6b4 \uc811\uadfc\ubc95\uc774\ub2e4. \uc774 \uacbd\ub85c\ub97c \uc790\uadf9\ud568\uc73c\ub85c\uc368 \uc5fc\uc99d\uc744 \uc904\uc774\uace0 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5\uc744 \uac1c\uc120\ud558\uba70 \uc5f0\uace8\uc744 \ubcf4\ud638\ud560 \uc218 \uc788\uc73c\uba70, metformine\uacfc \uac19\uc740 \ubd84\uc790\ub4e4\uc744 \uc0ac\uc6a9\ud55c \uc5f0\uad6c\uc5d0\uc11c \uc774\ub7ec\ud55c \ud6a8\uacfc\uac00 \uc785\uc99d\ub418\uc5c8\ub2e4.<\/p>\n
\ub9c8\uc9c0\ub9c9\uc73c\ub85c, \ud658\uc790\uc758 \uc720\uc804\uc801 \ubc0f \ubd84\uc790\uc801 \ud504\ub85c\ud30c\uc77c\uc5d0 \ub9de\ucdb0 \uce58\ub8cc\ub97c \uc870\uc808\ud558\ub294 \uc815\ubc00 \uc758\ud559 \uc811\uadfc\ubc95\uc740 \uad00\uc808\uc5fc \uad00\ub9ac\uc758 \ud328\ub7ec\ub2e4\uc784\uc744 \ubc14\uafc0 \uc218 \uc788\ub2e4. \ubc14\uc774\uc624\ub9c8\ucee4, \uace0\uae09 \uc601\uc0c1 \uae30\uc220, \uc778\uacf5\uc9c0\ub2a5 \uc54c\uace0\ub9ac\uc998\uc744 \uacb0\ud569\ud558\uc5ec, \uc5f0\uad6c\uc790\ub4e4\uc740 \uc704\ud5d8\uc5d0 \ucc98\ud55c \ud658\uc790\ub97c \uc870\uae30\uc5d0 \uc2dd\ubcc4\ud558\uace0 \ub9de\ucda4\ud615 \uce58\ub8cc\ub97c \uc81c\uacf5\ud558\uae30\ub97c \ud76c\ub9dd\ud55c\ub2e4. \ubaa9\ud45c\ub294 \uc99d\uc0c1\uc744 \uc644\ud654\ud558\ub294 \ub370 \uadf8\uce58\ub294 \uc758\ud559\uc5d0\uc11c \uc9c8\ubcd1\uc758 \uacbd\ub85c\ub97c \ubc14\uafb8\ub294 \uc758\ud559\uc73c\ub85c \ub118\uc5b4\uac00\ub294 \uac83\uc774\ub2e4.<\/p>\n
“`<\/p>\n
DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1038\/s41413-026-00540-6<\/a><\/p>\n Titre\u00a0:<\/strong> Novel therapeutic strategies for osteoarthritis: from mechanistic insights to precision medicine<\/p>\n Revue : <\/strong> Bone Research<\/p>\n \u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n Auteurs : <\/strong> Muhammad Umar; Ziling Wang; Jingwen Li; Zhen Li; Gang Li; Liping Tong; Di Chen<\/p>\n","protected":false},"excerpt":{"rendered":" “`html \uad00\uc808\uc5fc\uc740 \uc5f0\uace8\uc758 \ub2e8\uc21c \ub9c8\ubaa8\ub97c \ub118\uc5b4\uc120\ub2e4 \uad00\uc808\uc5fc\uc740 \uc804 \uc138\uacc4 5\uc5b5 \uba85 \uc774\uc0c1\uc5d0\uac8c \uc601\ud5a5\uc744 \ubbf8\uce58\uba70 \uadf8\ub4e4\uc758 \uc0b6\uc758 \uc9c8\uc744 \ud06c\uac8c \uc800\ud574\ud55c\ub2e4. \uc624\ub7ab\ub3d9\uc548 \uc5f0\uace8\uc758 \ub9c8\ubaa8\uc640 \uad00\ub828\ub41c \uc9c8\ubcd1\uc73c\ub85c \uc5ec\uaca8\uc84c\uc9c0\ub9cc, \ud604\uc7ac\ub294 \uad00\uc808 \uc804\uccb4\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uc9c8\ubcd1\uc73c\ub85c \uc778\uc2dd\ub418\uace0 \uc788\uc73c\uba70, \uc774\ub294 \ubf08, \uc778\ub300, \ud65c\uc561\ub9c9 \ubc0f \uae30\ud0c0 \uc870\uc9c1\ub4e4\uc744 \ud3ec\ud568\ud55c\ub2e4. \ud56d\uc5fc\uc99d\uc81c\ub098 \uc2a4\ud14c\ub85c\uc774\ub4dc\uc640 \uac19\uc740 \uc804\ud1b5\uc801\uc778 \uce58\ub8cc\ubc95\uc740 \uc99d\uc0c1\uc744 \uc644\ud654\uc2dc\ud0ac \uc218\ub294 \uc788\uc9c0\ub9cc, \uc9c8\ubcd1\uc758 \uc9c4\ud589\uc744 \uba48\ucd94\uac70\ub098 \uad00\uc808 \uae30\ub2a5\uc744… \uad00\uc808\uc5fc\uc740 \uc5f0\uace8\uc758 \ub2e8\uc21c \ub9c8\ubaa8\ub97c \ub118\uc5b4\uc120\ub2e4<\/span> \uacc4\uc18d \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,7,8],"tags":[],"class_list":["post-23","post","type-post","status-publish","format-standard","hentry","category-2","category-7","category-8","entry"],"_links":{"self":[{"href":"https:\/\/themedicinereview.com\/ko\/wp-json\/wp\/v2\/posts\/23","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/themedicinereview.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/themedicinereview.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/themedicinereview.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/themedicinereview.com\/ko\/wp-json\/wp\/v2\/comments?post=23"}],"version-history":[{"count":1,"href":"https:\/\/themedicinereview.com\/ko\/wp-json\/wp\/v2\/posts\/23\/revisions"}],"predecessor-version":[{"id":24,"href":"https:\/\/themedicinereview.com\/ko\/wp-json\/wp\/v2\/posts\/23\/revisions\/24"}],"wp:attachment":[{"href":"https:\/\/themedicinereview.com\/ko\/wp-json\/wp\/v2\/media?parent=23"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/themedicinereview.com\/ko\/wp-json\/wp\/v2\/categories?post=23"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/themedicinereview.com\/ko\/wp-json\/wp\/v2\/tags?post=23"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}